:root{
  --navy-950:#061f33;
  --navy-900:#082f4d;
  --navy-800:#0a456f;
  --blue-600:#2f91c9;
  --blue-500:#459bd0;
  --cyan:#22bee5;
  --orange:#ff5b2d;
  --ink:#13232d;
  --muted:#61717c;
  --line:#d9e5eb;
  --soft:#f3f8fb;
  --white:#ffffff;
  --shell:1180px;
  --radius:24px;
  --shadow:0 28px 70px rgba(5,37,60,.12);
}

*{box-sizing:border-box}
html{scroll-behavior:smooth}
body{
  margin:0;
  font-family:Inter,ui-sans-serif,-apple-system,BlinkMacSystemFont,"Segoe UI",Roboto,Helvetica,Arial,sans-serif;
  color:var(--ink);
  background:var(--white);
  line-height:1.55;
  -webkit-font-smoothing:antialiased;
}
img,svg{display:block;max-width:100%}
a{color:inherit}
button,input,textarea{font:inherit}
.shell{width:min(var(--shell),calc(100% - 48px));margin-inline:auto}
.skip-link{position:absolute;left:-9999px;top:auto}
.skip-link:focus{left:16px;top:16px;z-index:999;background:#fff;padding:10px 14px;border-radius:8px}

.site-header{
  position:fixed;top:0;left:0;right:0;z-index:50;
  transition:background .25s ease,border-color .25s ease,box-shadow .25s ease;
  border-bottom:1px solid transparent;
}
.site-header.scrolled{
  background:rgba(255,255,255,.94);
  border-bottom-color:rgba(217,229,235,.9);
  box-shadow:0 8px 26px rgba(3,31,50,.06);
  backdrop-filter:blur(18px);
}
.nav{height:82px;display:flex;align-items:center;justify-content:space-between;gap:36px}
.wordmark{
  display:inline-flex;align-items:center;gap:10px;
  color:var(--navy-900);text-decoration:none;
  font-size:16px;font-weight:800;letter-spacing:.16em;
}
.wordmark img{width:40px;height:40px;object-fit:contain}
.nav-links{display:flex;align-items:center;gap:30px}
.nav-links a{
  color:#29404f;text-decoration:none;font-weight:650;font-size:14px;
  transition:color .2s ease;
}
.nav-links a:hover{color:var(--blue-600)}
.nav-contact{border:1px solid rgba(8,47,77,.45);padding:10px 16px;border-radius:999px}
.menu-button{display:none;background:none;border:0;padding:8px}
.menu-button span{display:block;width:25px;height:2px;background:var(--navy-900);margin:6px 0}

.hero{
  min-height:760px;
  position:relative;
  display:flex;align-items:center;
  padding:132px 0 84px;
  overflow:hidden;
  background:
    radial-gradient(circle at 72% 25%,rgba(34,190,229,.12),transparent 28%),
    linear-gradient(135deg,#edf8fd 0%,#ffffff 55%,#f5fafd 100%);
}
.hero-grid{display:grid;grid-template-columns:1.02fr .98fr;gap:68px;align-items:center;position:relative;z-index:2}
.hero-orbit{position:absolute;border:1px solid rgba(47,145,201,.16);border-radius:50%;pointer-events:none}
.orbit-one{width:680px;height:680px;right:-235px;top:-135px}
.orbit-two{width:450px;height:450px;right:-90px;top:20px;border-color:rgba(255,91,45,.13)}
.kicker{margin:0 0 20px;font-size:12px;font-weight:800;letter-spacing:.19em;color:var(--blue-600)}
.kicker-light{color:#8fddf2}
h1,h2,h3{margin:0;color:var(--navy-950);letter-spacing:-.035em;line-height:1.07}
h1{font-size:clamp(54px,6.7vw,86px);max-width:780px}
h2{font-size:clamp(38px,4.35vw,58px)}
h3{font-size:22px}
.hero-lead{
  max-width:670px;margin:28px 0 32px;
  color:#40545f;font-size:21px;line-height:1.62;
}
.hero-actions{display:flex;gap:14px;flex-wrap:wrap}
.button{
  display:inline-flex;align-items:center;justify-content:center;
  border-radius:999px;padding:13px 21px;text-decoration:none;
  border:0;font-weight:750;cursor:pointer;transition:transform .2s ease,box-shadow .2s ease,background .2s ease;
}
.button:hover{transform:translateY(-1px)}
.button-primary{background:var(--navy-900);color:white;box-shadow:0 10px 24px rgba(8,47,77,.15)}
.button-primary:hover{background:var(--navy-950)}
.button-ghost{background:white;border:1px solid #b9ced9;color:var(--navy-900)}
.button-orange{background:var(--orange);color:white}
.hero-tags{display:flex;flex-wrap:wrap;gap:10px;margin-top:28px}
.hero-tags span{
  font-size:12px;font-weight:700;color:#536773;
  padding:8px 11px;border:1px solid #d6e4eb;border-radius:999px;background:rgba(255,255,255,.72)
}

.visual-card{
  position:relative;background:rgba(255,255,255,.87);
  border:1px solid rgba(190,215,227,.82);
  border-radius:30px;padding:24px;
  box-shadow:var(--shadow);backdrop-filter:blur(10px);
}
.visual-label{font-size:10px;letter-spacing:.2em;color:var(--blue-600);font-weight:850}
.cell-diagram{margin-top:2px}
.route{fill:none;stroke:var(--cyan);stroke-width:2.5;stroke-dasharray:7 10;opacity:.55}
.cell{stroke-width:4}.cell.quiet{fill:url(#cellFill);stroke:#9fcee3}.cell.target{fill:url(#targetFill);stroke:var(--orange)}
.nucleus{fill:#cde5f0}.target-dots circle{fill:var(--orange)}
.antibody path{stroke:var(--navy-900);stroke-width:13;stroke-linecap:round;fill:none}
.antibody .accent-arm{stroke:var(--cyan);stroke-width:8}
.diagram-title{font-size:16px;font-weight:800;fill:var(--navy-900)}
.diagram-caption{font-size:14px;fill:#667a85}
.visual-footer{display:grid;grid-template-columns:auto 1fr;gap:12px;align-items:flex-start;padding:14px 4px 2px;border-top:1px solid #e0eaef}
.visual-footer p{margin:0;font-size:13px;color:#637681}
.signal{width:9px;height:9px;border-radius:50%;background:var(--orange);margin-top:5px;box-shadow:0 0 0 5px rgba(255,91,45,.11)}

.proof-bar{border-top:1px solid var(--line);border-bottom:1px solid var(--line);background:white}
.proof-grid{display:grid;grid-template-columns:repeat(4,1fr)}
.proof-grid>div{display:flex;gap:12px;align-items:center;padding:22px 20px;border-right:1px solid var(--line)}
.proof-grid>div:last-child{border-right:0}
.proof-grid strong{font-size:12px;color:var(--orange)}
.proof-grid span{font-size:13px;font-weight:750;color:#3f5562}

.section{padding:108px 0}
.section-light{background:#fff}
.section-white{background:#fff}
.section-soft{background:var(--soft)}
.section-blue{background:var(--navy-900);color:white}
.split-intro{display:grid;grid-template-columns:1.08fr .92fr;gap:76px;align-items:start}
.large-copy{font-size:20px;line-height:1.68;color:#425762}
.large-copy p{margin-top:0}
.feature-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:20px;margin-top:58px}
.feature-card{
  min-height:240px;padding:28px;border:1px solid var(--line);border-radius:var(--radius);
  background:linear-gradient(180deg,#fff,#fbfdfe);
}
.feature-icon{display:block;margin-bottom:42px;font-size:11px;font-weight:850;color:var(--orange)}
.feature-card h3{margin-bottom:13px}
.feature-card p{margin:0;color:var(--muted);font-size:15px}

.section-head{max-width:820px}
.section-head-light h2{color:white}
.section-head-light>p:last-child{max-width:700px;color:#cfe0e9;font-size:18px}
.process{display:grid;grid-template-columns:repeat(4,1fr);gap:1px;margin-top:58px;background:rgba(255,255,255,.14);border:1px solid rgba(255,255,255,.14);border-radius:26px;overflow:hidden}
.process-step{background:rgba(255,255,255,.055);padding:30px;min-height:245px}
.step-no{font-size:11px;color:#8bdcf3;font-weight:850;margin-bottom:55px}
.process-step h3{color:white;margin-bottom:12px}
.process-step p{margin:0;color:#c7dbe5;font-size:15px}

.program-layout{display:grid;grid-template-columns:1.08fr .92fr;gap:78px;align-items:center}
.program-copy>p:not(.kicker){color:#5a6c77}
.program-status{display:grid;grid-template-columns:repeat(3,1fr);gap:12px;margin-top:34px}
.program-status>div{padding:16px;border-radius:16px;background:var(--soft);border:1px solid #e3edf2}
.program-status span{display:block;font-size:10px;letter-spacing:.12em;text-transform:uppercase;color:var(--blue-600);font-weight:850;margin-bottom:6px}
.program-status strong{display:block;font-size:13px;line-height:1.35;color:var(--navy-900)}
.strategy-card{
  border-radius:28px;padding:34px;background:var(--navy-950);color:white;
  box-shadow:var(--shadow);position:relative;overflow:hidden;
}
.strategy-card:before{
  content:"";position:absolute;width:260px;height:260px;border:1px solid rgba(34,190,229,.18);
  border-radius:50%;right:-110px;top:-120px;
}
.card-label{margin:0 0 30px;font-size:10px;letter-spacing:.18em;font-weight:850;color:#8bdcf3}
.target-pair{display:grid;grid-template-columns:1fr auto 1fr;align-items:center;gap:12px}
.target-box{background:white;color:var(--navy-900);padding:21px;border-radius:18px;text-align:center}
.target-box span{display:flex;width:34px;height:34px;align-items:center;justify-content:center;margin:0 auto 9px;border-radius:50%;background:#edf7fb;color:var(--blue-600);font-weight:850}
.target-box p{margin:0;font-size:13px;font-weight:750;line-height:1.4}
.pair-symbol{font-size:28px;color:var(--orange);font-weight:800}
.down-arrow{text-align:center;font-size:26px;color:var(--cyan);margin:10px 0}
.selectivity-box{display:flex;flex-direction:column;gap:4px;padding:20px;border-radius:18px;background:rgba(255,255,255,.08);border:1px solid rgba(255,255,255,.13)}
.selectivity-box strong{font-size:17px}.selectivity-box span{font-size:13px;color:#c7dbe5}
.mini-separator{height:1px;background:rgba(255,255,255,.13);margin:26px 0 18px}
.confidential-note{font-size:12px;color:#9fb9c7;margin:0}

.expansion-layout{display:grid;grid-template-columns:.85fr 1.15fr;gap:70px;align-items:center}
.expansion-layout>div:first-child>p:last-child{color:var(--muted)}
.pipeline{display:flex;align-items:center}
.pipeline-item{min-width:118px;text-align:center}
.pipeline-item span{
  display:flex;width:50px;height:50px;align-items:center;justify-content:center;margin:0 auto 11px;
  border-radius:50%;background:white;border:1px solid #b5ccd8;color:var(--navy-900);font-size:12px;font-weight:850
}
.pipeline-item.active span{background:var(--navy-900);border-color:var(--navy-900);color:white}
.pipeline-item strong{display:block;color:var(--navy-900);font-size:14px}
.pipeline-item small{display:block;color:#72838d;font-size:11px;margin-top:3px}
.pipeline-line{height:1px;background:#b9cdd7;flex:1;min-width:18px}

.company-grid{display:grid;grid-template-columns:.72fr 1.28fr;gap:74px;align-items:start}
.founder-card{display:grid;grid-template-columns:auto 1fr;gap:24px;padding:34px;border:1px solid var(--line);border-radius:var(--radius);background:#fbfdfe}
.founder-monogram{display:flex;align-items:center;justify-content:center;width:72px;height:72px;border-radius:18px;background:var(--navy-900);color:white;font-weight:850;letter-spacing:.06em}
.founder-card h3{margin-top:3px}.founder-role{margin:6px 0 18px;color:var(--blue-600);font-size:12px;font-weight:800;letter-spacing:.12em;text-transform:uppercase}
.founder-card p:not(.founder-role){color:var(--muted)}

.contact-section{position:relative;overflow:hidden;background:linear-gradient(135deg,var(--navy-900),var(--navy-950));color:white}
.contact-orbit{position:absolute;width:620px;height:620px;border-radius:50%;border:1px solid rgba(34,190,229,.16);right:-220px;top:-250px}
.contact-grid{display:grid;grid-template-columns:.88fr 1.12fr;gap:76px;align-items:start;position:relative}
.contact-copy h2{color:white}.contact-copy>p:last-child{color:#c7dbe5;font-size:17px;max-width:520px}
.contact-form{background:white;color:var(--ink);padding:30px;border-radius:26px;box-shadow:0 24px 70px rgba(0,13,24,.22)}
.form-row{display:grid;grid-template-columns:1fr 1fr;gap:15px}
.contact-form label{display:block;font-size:12px;font-weight:800;color:#415763;margin-bottom:14px}
.contact-form input,.contact-form textarea{
  display:block;width:100%;margin-top:7px;padding:12px 13px;border:1px solid #cbdbe3;border-radius:11px;background:white;color:var(--ink);
}
.contact-form input:focus,.contact-form textarea:focus{outline:3px solid rgba(47,145,201,.12);border-color:var(--blue-600)}
.hidden-field{display:none}
.form-footer{display:flex;align-items:center;justify-content:space-between;gap:18px;margin-top:4px}
.form-footer p{margin:0;color:#788a94;font-size:11px;max-width:270px}

.site-footer{background:#051a2a;color:#c2d3dd;padding:44px 0 24px}
.footer-grid{display:grid;grid-template-columns:1.15fr 1fr .65fr;gap:54px}
.footer-wordmark{color:white}.footer-wordmark img{width:34px;height:34px}
.footer-grid>div:first-child>p{font-size:13px;color:#96afbd}
.footer-meta p{margin:2px 0;font-size:12px}.footer-meta strong{color:white}
.footer-links{display:flex;flex-direction:column;gap:8px;align-items:flex-start}
.footer-links a{font-size:12px;text-decoration:none}.footer-links a:hover{color:white}
.footer-bottom{display:flex;justify-content:space-between;gap:24px;border-top:1px solid rgba(255,255,255,.1);margin-top:36px;padding-top:18px;font-size:10px;color:#76909e}

.reveal{opacity:1;transform:none}\n.js .reveal{opacity:0;transform:translateY(18px);transition:opacity .65s ease,transform .65s ease}\n.js .reveal.is-visible{opacity:1;transform:none}

@media (prefers-reduced-motion:reduce){
  html{scroll-behavior:auto}
  .reveal{opacity:1;transform:none;transition:none}
  .button{transition:none}
}

@media(max-width:980px){
  .nav-links{
    position:absolute;left:24px;right:24px;top:74px;display:none;flex-direction:column;align-items:stretch;gap:0;
    background:white;border:1px solid var(--line);border-radius:18px;box-shadow:var(--shadow);padding:10px
  }
  .nav-links.open{display:flex}
  .nav-links a{padding:12px 14px}.nav-contact{border:0;border-radius:10px;background:var(--soft)}
  .menu-button{display:block}
  .hero{min-height:auto}
  .hero-grid,.split-intro,.program-layout,.expansion-layout,.company-grid,.contact-grid{grid-template-columns:1fr}
  .hero-grid{gap:40px}.hero-art{max-width:700px}
  .proof-grid{grid-template-columns:1fr 1fr}.proof-grid>div:nth-child(2){border-right:0}
  .feature-grid{grid-template-columns:1fr 1fr}.process{grid-template-columns:1fr 1fr}
  .company-title{max-width:700px}
}
@media(max-width:680px){
  .shell{width:min(100% - 30px,var(--shell))}
  .nav{height:70px}.wordmark{font-size:14px}.wordmark img{width:34px;height:34px}
  .hero{padding:116px 0 66px}
  h1{font-size:49px}.hero-lead{font-size:18px}
  .section{padding:76px 0}
  .proof-grid,.feature-grid,.process,.program-status{grid-template-columns:1fr}
  .proof-grid>div{border-right:0;border-bottom:1px solid var(--line)}.proof-grid>div:last-child{border-bottom:0}
  .process{gap:1px}.process-step{min-height:auto}.step-no{margin-bottom:28px}
  .target-pair{grid-template-columns:1fr}.pair-symbol{transform:rotate(90deg)}
  .pipeline{display:grid;grid-template-columns:1fr;gap:10px}.pipeline-line{width:1px;height:22px;margin:0 auto}
  .founder-card{grid-template-columns:1fr}.form-row{grid-template-columns:1fr}.form-footer{align-items:flex-start;flex-direction:column}
  .footer-grid{grid-template-columns:1fr}.footer-bottom{flex-direction:column}
}


/* --- Science validation --- */
.science-section{
  background:linear-gradient(180deg,#f7fbfd 0%,#ffffff 100%);
  border-top:1px solid #e2edf2;
  border-bottom:1px solid #e2edf2;
}
.science-grid{
  display:grid;
  grid-template-columns:1fr 1fr;
  gap:72px;
  align-items:center;
}
.science-copy>p:not(.kicker){color:var(--muted)}
.evidence-panel{
  border:1px solid var(--line);
  border-radius:28px;
  background:white;
  padding:34px;
  box-shadow:0 20px 55px rgba(5,37,60,.08);
}
.evidence-label{
  margin-bottom:18px;
  font-size:10px;
  font-weight:850;
  letter-spacing:.18em;
  color:var(--blue-600);
}
.evidence-panel h3{
  font-size:28px;
  line-height:1.18;
  margin-bottom:16px;
}
.evidence-panel>p{
  margin:0;
  color:var(--muted);
}
.evidence-points{
  display:grid;
  grid-template-columns:repeat(3,1fr);
  gap:10px;
  margin:28px 0;
}
.evidence-points>div{
  padding:15px;
  border-radius:14px;
  background:var(--soft);
  border:1px solid #e3edf2;
}
.evidence-points span{
  display:block;
  margin-bottom:7px;
  font-size:10px;
  font-weight:850;
  color:var(--orange);
}
.evidence-points p{
  margin:0;
  font-size:12px;
  line-height:1.4;
  font-weight:700;
  color:#445b67;
}
.text-link{
  color:var(--navy-900);
  font-size:13px;
  font-weight:800;
  text-decoration:none;
  border-bottom:1px solid #a9c5d3;
  padding-bottom:2px;
}
.text-link:hover{color:var(--blue-600)}

/* --- Biotech pipeline --- */
.development-pipeline{
  display:grid;
  grid-template-columns:repeat(4,1fr);
  gap:0;
  margin-top:34px;
}
.pipeline-stage{position:relative}
.stage-track{
  position:relative;
  height:12px;
  background:#dce8ee;
}
.pipeline-stage:first-child .stage-track{border-radius:999px 0 0 999px}
.pipeline-stage:last-child .stage-track{border-radius:0 999px 999px 0}
.stage-track span{position:absolute;inset:0}
.pipeline-stage.done .stage-track span{background:var(--navy-900)}
.pipeline-stage.active .stage-track span{background:linear-gradient(90deg,var(--blue-600),var(--cyan))}
.pipeline-stage.next .stage-track span{width:0}
.pipeline-stage small{
  display:block;
  margin-top:10px;
  padding-right:10px;
  color:#5e707a;
  font-size:11px;
  line-height:1.3;
  font-weight:750;
}
.pipeline-stage.active small{color:var(--navy-900)}
.pipeline-caption{
  margin-top:16px !important;
  font-size:12px !important;
  color:#71838d !important;
}
.founder-credentials{
  margin:0 0 18px;
  color:var(--navy-900) !important;
  font-size:13px;
  line-height:1.55;
  font-weight:750;
}

@media(max-width:980px){
  .science-grid{grid-template-columns:1fr}
}
@media(max-width:680px){
  .evidence-points{grid-template-columns:1fr}
  .development-pipeline{grid-template-columns:1fr;gap:9px}
  .pipeline-stage .stage-track,
  .pipeline-stage:first-child .stage-track,
  .pipeline-stage:last-child .stage-track{border-radius:999px}
  .pipeline-stage small{margin-top:5px}
}

.contact-email{
  margin-top:26px;
  display:flex;
  flex-direction:column;
  gap:4px;
}
.contact-email span{
  font-size:10px;
  font-weight:850;
  letter-spacing:.16em;
  text-transform:uppercase;
  color:#8fddf2;
}
.contact-email a{
  color:white;
  font-size:20px;
  font-weight:750;
  text-decoration:none;
}
.contact-email a:hover{color:#8fddf2}
.footer-meta a{color:inherit;text-decoration:none}
.footer-meta a:hover{color:white}